Post-Doctoral Associate

The Liu lab uses a combination of biochemical and structural (Cryo-EM and X-ray crystallography) techniques to primarily study macromolecules and macromolecular complexes involved in pathogen infection, with a particular focus on transcriptional complexes. Transcription is the first and central step of gene expression, in which the DNA template is copied into RNA by the RNA polymerase, and defects in transcription and its regulation can lead to a variety of severe human diseases. The long-term goal is to provide a structural basis for understanding the mechanisms of transcription initiation, elongation and termination by RNA polymerase. The employer retains the right to change or assign other duties to this position.

Responsibilities

* Conduct and lead scientific research efforts in the study of how transcription happens and how it is regulated by various transcription factors.
* Collaborate with researchers to provide a structural basis for understanding the mechanisms of transcription initiation, elongation and termination by RNAP.
* Study the transition of transcription from initiation to termination phases, the regulation of different transcription stages by various factors and the mechanisms by which RNAP translocates with nucleotide addition.
* Use cryo-electron microscopy (cryo-EM) and X-ray crystallography.
* Conduct biochemical experiments.
* Analyze research methods and collect information and related studies to support the research claims.
* Write research reports and give scientific presentations.
* Maintain a safe, clean and functional laboratory.

Focus of Job Responsibilities

70% - Ongoing Research

* Design and implementation of hypothesis-driven research projects.

15% - Analysis & Review

* Analysis and review of generated data and reviewing previously reported scientific literature.

15% - Scientific writing

* Including reporting research findings in manuscripts for publication in peer-reviewed biomedical journals and grant writing.
* Generation of figures for manuscripts and grants proposals.

Flexible Work Profile
The Research and Innovation Office (RIO) and The Hormel Institute endorses a "work with flexibility" approach that offers a welcoming and flexible work environment where everyone is inspired to do their best. Work location options include working fully remote, partially remote, or entirely in the office and are based on the work of the position. Some on-site work may be necessary for certain positions, even those designated as fully remote. Because we are a land-grant institution that serves the state, the University will continue to- in most cases- expect employees to live in Minnesota.

This position has been designated as eligible for Flexible Work Profile One.
Flexible Work Profile One, Office/Lab-Based - is expected to work primarily on-site in the office/lab. Only occasionally and inconsistently working remotely. Your office will be located at The Hormel Institute in Austin, Minnesota. The Hormel Institute management retains the right to modify flexible work arrangement agreements on a temporary or permanent basis for any reason at any time.

Required Qualifications

* Ph.D., DDS, DVM, JD, MD or equivalent.

Preferred Qualifications

* Experience in structural biology, particularly interpretation of intermediate resolution EM and X-ray maps and model building.
* Strong laboratory skills in molecular biology, biochemistry, and protein expression/purification.
* Experience in X-ray crystallography (data processing, phase determination, model-building and refinement) or electron cryo-microscopy (grid preparation and data processing).

Founded in 1942 by Jay C. Hormel and The Hormel Foundation, The Hormel Institute, University of Minnesota, makes scientific advancements that enhance wellbeing and extend human life. For more than 80 years, we have pursued our mission to conduct research and provide education in the biological sciences with applications in medicine and agriculture. A part of the University of Minnesota's Research and Innovation Office, The Hormel Institute partners with the region's leading biomedical research facilities, including Mayo Clinic.

Pay Range: $63,480-$77,076; depending on education/qualifications/experience

Please visit the Benefits for Postdoctoral Candidates website for more information regarding benefit eligibility.

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training
• Medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and life insurance
• Employee wellbeing program
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail jobcentr@umn.edu.

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.

At the University of Minnesota, we are proud to be recognized by Forbes as a Best Employer for Company Culture (2026), Best Employer for Women (2023, 2025, 2026), and Best Employer by State (2022-2026). In 2026, we also received Culture Excellence & Industry Awards recognition for employee appreciation and work-life flexibility.