Senior Research Scientist - Targeted LNP Delivery (Discovery)
 Vertex Pharmaceuticals Incorporated | |
paid time off, 401(k)
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 United States, California, San Diego | |
| 11010 Torreyana Road (Show on map) | |
 Feb 26, 2026 | |
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Job Description We are seeking an innovative and highly motivated Senior Scientist to lead discovery-stage development of targeted lipid nanoparticle (LNP) platforms. This role will drive receptor target identification and validation, establish high-throughput ligand conjugation workflows, and develop scalable assay systems to enable systematic screening of targeted LNP constructs. The successful candidate will build a modular, data-driven targeting engine capable of evaluating single and multi-ligand strategies across multiple cell types and therapeutic indications. This is an onsite position in San Diego. KEY RESPONSIBILITIES: Receptor Target Identification & Validation
High-Throughput LNP-Ligand Conjugation Design and implement scalable LNP-ligand conjugation workflows using chemical and affinity-based strategies. Develop high-throughput systems capable of screening:
Establish quantitative methods for measuring conjugation efficiency, ligand density, and stability. Compare and optimize chemical versus affinity-based conjugation approaches. Assay Development & Screening Develop and execute robust in vitro assays to assess:
Establish high-throughput screening workflows capable of evaluating 30-50+ targeted constructs per campaign. Define quantitative performance metrics for ligand and construct prioritization. LNP Development (collaborative)
KNOWLEDGE AND SKILLS:
EDUCATION AND EXPERIENCE:
#LI-KM1 #LI-Onsite Pay Range: $121,600 - $182,400Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site DesignatedFlex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com | |