New

Postdoctoral Fellow

Massachusetts General Hospital
United States, Massachusetts, Boston
114 16th Street (Show on map)
Nov 21, 2025
The Jorfi Laboratory and the Griciuc Laboratory in the Genetics and Aging Research Unit at the Department of Neurology, Massachusetts General Hospital are seeking a highly motivated Post-Doctoral Research Fellow to conduct research in neuroimmunology with an emphasis on innate immune receptors, human iPSC-derived cells, and animal models of Alzheimer's disease. Our collaborative teams investigate how immune cells interact with other cell types in the brain in the context of neurodegeneration, utilizing iPSC-derived myeloid and neural lineages, 3D human multicellular systems, and animal models. The Postdoctoral Fellow will contribute to ongoing efforts to model neuroimmune mechanisms and advance next-generation therapeutic strategies for Alzheimer's disease. The Post-Doctoral Research Fellow will be expected to: 1.Make strong intellectual contributions to scientific strategy 2.Serve as a subject matter expert in relevant experimental methods 3.Lead and contribute to manuscripts, reports, grants, and presentations 4.Work collaboratively in a multidisciplinary research environment This position is a multi-year, fully funded opportunity within a dynamic and highly interactive scientific community at the Genetics and Aging Research Unit under the leadership of Dr. Rudolph E. Tanzi. Qualifications The ideal candidate will have: A PhD in neurobiology, immunology, bioengineering, stem cell biology, or a related field. Strong background in one or more of the following: Human iPSC differentiation (myeloid, microglial, or neuronal lineages) Neuroimmunology or inflammation biology CRISPR or other genetic engineering tools Flow cytometry, imaging, or functional immune assays In vivo mouse models of Alzheimer's disease Experience with intrahippocampal parenchymal and/or intracerebroventricular (ICV) injections in mouse brain is preferred but not required Evidence of scientific independence, including first-author publications in top-tier journals. Excellent communication, organizational, and writing skills. Interest in conceiving and designing new projects aligned with our research focus. Ability to work effectively as part of a collaborative, multidisciplinary team. To Apply Please submit yourCVand aletter of interestto: Dr. Jorfi (mjorfi@mgh.harvard.edu) and Dr. Griciuc (griciuc.ana@mgh.harvard.edu) In your cover letter, please describe your overall research interests and goals, why this opportunity aligns with your career development, and what you aim to learn as part of the team. The General Hospital Corporation is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.