Principal Scientist - PBPK and Pharmacometrics, Modeling and Simulation, Clinical Pharmacology

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The Clinical Pharmacology Department at Genentech, Inc. is seeking Ph.D. level Senior Scientist, Principal Scientist, or Senior Principal Scientist who is driven to use cutting edge modeling approaches to advance the clinical development of novel drug candidates to join our diverse group of pharmacometricians, system modelers (PBPK or QSP), advanced programmers, artificial intelligence/machine learning scientists, and clinical pharmacologists. This individual will be responsible for the development and implementation of Clinical Pharmacology (Clin Pharm) and/or Modeling & Simulation (M&S) strategy, in order to ensure that the right drug is administered to the right patient at the right dose via the right route. Physiologically-based Pharmacokinetic (PBPK) modeling will be a key focus of this position. Key technical responsibilities are to strategize, plan, execute, and report PBPK M&S independently, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences. A qualified candidate could be responsible for Clin Pharm strategy/support such as leading the design, conduct, and reporting of Clin Pharm studies, as well as other M&S strategy/support such as population PK/PD models, disease models, statistical models, quantitative system pharmacology (QSP) models, clinical trial simulations, literature meta-analysis, machine learning/deep learning. Other responsibilities may include planning, writing, and reviewing relevant clinical documents such as study protocols, analysis plans, reports, and regulatory documents. These will be accomplished by working in close partnership with other scientists in Clinical Pharmacology, Clinical Science, Biostatistics, Translational PKPD, DMPK, Translational Safety, Biomarker, Diagnostics, Regulatory, RWD (Real World Data), and other functions on project teams. The successful candidate should be a forward thinking scientist capable of working effectively across diverse regions, cultures, and time zones, creating an environment of belonging and inclusion.

The Opportunity:

As a member of the DevSci/ Clinical Pharmacology team, you will:

• Have solid expertise in quantitative pharmacology and strong PBPK modeling

• Have rich hands-on experience in conducting PBPK modeling using Simcyp, Gastroplus, PKSim or other relevant software

• Hands-on experience with other M&S softwares, such as R, NONMEM, SimBiology, Python, is a big plus

• Experience working on cross-functional teams as a Clinical Pharmacology Lead and/or Modeling & Simulation Lead during clinical drug development is highly preferred

• Experience with interaction with regulatory agencies is desired

• Have excellent communication and interpersonal skills, as well as the demonstrated ability to work effectively in cross-functional teams

• Should thrive and work well in a fast-paced, multi-tasked, and hands-on environment. For an experienced candidate, demonstrated impact on drug development through quantitative approaches is required

• Have a strong track-record of leadership skills and success in influencing senior stakeholders is critical for success

Who You Are:

• A Ph.D. or equivalent in Pharmaceutical Science, Pharmacometrics, Data Science, Biomedical or Chemical Engineering, or related discipline

• 0+ year (for Senior Scientist), 3+ years (for Principal Scientist), or 7+ years (for Senior Principal Scientist) of industry, regulatory, and/or related post-doctoral experience

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $148,200- $275,200 of the hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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