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Position:
Scientist 2, Formulations
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Job Id:
4330
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# of Openings:
1
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General Summary
This position is responsible for the preparation and analysis of test article formulations for preclinical studies, ensuring accuracy, stability, and consistency in all dosing materials. This role requires a strong understanding of dose formulation procedures, analytical techniques, and regulatory standards, particularly Good Laboratory Practices (GLP). The Scientist 2, Formulations will apply an understanding of scientific laboratory methods and techniques with an ability to work well within a team and independently on routine tasks. This position provides clients with detailed summaries pertaining to sample life-cycle, dose formulation feedback and clearly identifying discrepancies and/or problem areas. This position will report directly to the HTS Director and performs tasks with little to no supervision. This position supports research teams/groups led by other individuals and is required to obtain or take direction from those outside of the traditional reporting structure. This direction may include day-to-day task direction to ensure quality of the work completed. This position also supports and promotes innovative solutions and strategies and communicated objectives and timelines to management. Provides guidance and training to more junior Laboratory Technicians ensuring Good Laboratory Practices.
Essential Duties & Responsibilities
- Observes and executes activities consistent with study protocols, Standard Operating Procedures (SOPs) or Laboratory Methods, Good Laboratory Practices (GLP) regulations, and safety and health practices.
- Conducts routine scientific experiments
- Resolves basic to moderately complex problems requiring the application of standard procedures and techniques.
- Prepare and characterize dose formulations (solutions, suspensions, or other vehicles) for administration in non-clinical studies.
- Conduct dose formulation analysis, including concentration verification, homogeneity, and stability assessments using appropriate analytical techniques (e.g., HPLC, UV-Vis, LC-MS).
- Develop and optimize formulation methods for new compounds and troubleshoot formulation challenges.
- Accurately document all formulation preparation and analytical procedures in compliance with GLP requirements.
- Collaborate with toxicologists, virologists, oncologists, and analytical chemists to ensure alignment of formulation specifications with study protocols.
- Maintain formulation and analytical equipment, ensuring calibration and validation as needed.
- Participate in internal and external audits; contribute to the resolution of audit findings and CAPAs.
- Train and mentor junior staff in dose formulation techniques and GLP documentation practices.
- Assist in reviewing and writing SOPs, protocols, and study reports related to dose formulation activities.
- Performs experimental procedures under minimal to no supervision.
- Provides resolutions to a diverse range of problems.
- Exercises judgment in conducting laboratory operations procedures along with recognizing, postulating sources of deviations, addressing where possible and reporting deviations from expected results.
- Performs all work tasks following laboratory safety requirements.
- Attends departmental, other necessary meetings and training sessions pertinent to work.
- Functions as Subject Matter Expert on Specific Laboratory Operation Functions: Formulation, Sample Preparation.
- Maintains organization and record keeping of the compound and sample repositories.
- Assists in populating and updating the sample management and in-vivo databases.
- Coordinates, prepares, executes, and assists with the following:
- Dose Formulation related activities
- Receipt of samples;
- Labeling of research sample tubes/containers;
- Reagent preparation;
- Sample preparation;
- Dose formulations;
- Reagent and supply acquisition and purchase; and
- Sample disposition (store and dispose).
- Responsible for maintenance schedules for laboratory equipment.
- Maintains, cleans and checks calibration of instrumentation including but not limited to pipettes, centrifuges, balances, freezers and water baths at all SR Facilities.
- Supports implementation of new systems, techniques and strategies.
- Provides support to after-hour project deliverables.
- Supports and responds to after-hour alarms and/or other job critical emergencies.
Requirements/Minimum Qualifications
- Education and Experience
- Master's in Pharmaceutical Sciences, Chemistry, Biology, or related discipline with 8+ years of relevant experience in industry
- Proficient in analytical techniques such as HPLC, LC-MS, and UV-Vis spectroscopy for formulation analysis.
- Demonstrated knowledge of basic study design and execution.
- Understanding of GLP guidelines relevant to preclinical research.
- Strong attention to detail with excellent organizational and documentation skills.
- Ability to work both independently and collaboratively in a fast-paced research environment.
- Effective written and verbal communication skills.
- Demonstrated ability to train technicians
- Ability to observe and follow appropriate safety and study requirements by reading, understanding, and performing Standard Operating Procedures, Good Laboratory Practices (GLP) requirements, Chemical Hygiene Plan and study protocols.
- Ability to work overtime when necessary.
- This position requires the ability to meet all entry requirements, including medical and vaccination requirements for work in a BSL-2 laboratory environment. Immunizations are required for this position and are determined by the study/agent. Some examples include Tetanus, Hepatitis B, Smallpox, Polio, and Influenza.
Preferred Qualifications
* Ph.D. in Pharmaceutical Sciences, Chemistry, Biology, or related discipline with 8+ years of relevant experience in industry
- Experience with a wide range of formulation types (e.g., suspensions, emulsions, parenterals).
- Familiarity with electronic laboratory notebooks (ELNs) and laboratory information management systems (LIMS).
- Previous experience in IND-enabling studies.
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Apply for this Position
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Southern Research Institute
Jun 27, 2025 