Post-Doctoral Associate

Work Arrangement:
* The position is expected to work primarily on-site. Your work location will be in Wallin Biomedical Biosciences.
* The Department retains the right to modify flexible work arrangement agreements on a temporary or permanent basis for any reason at any time.

All required qualifications must be documented on application materials.
Required Qualifications:
* PhD in Immunology, Molecular Biology, or a closely related biomedical field
* Strong foundation in cellular and molecular immunology, with demonstrated expertise in T cell and dendritic cell biology
* Extensive hands-on experience with mouse models of infection, inflammation, and immune memory
* Proficient in flow cytometry, including high-dimensional and cell-sorting techniques, and immune phenotyping of primary cells
* Skilled in molecular biology and protein biochemistry, including qPCR, shRNA knockdown, cloning, western blotting, and MHC tetramer generation
* Experience with RNA-seq data analysis
* Strong written and verbal communication skills, demonstrated through peer-reviewed publications and conference presentations

Preferred Qualifications:
* Experience with antigen-specific immune monitoring (e.g., MHC class I tetramers)
* Experience in confocal imaging, ELISA, and viral assays
* Experience with bioinformatic workflows and interpretation of immune transcriptomic data
* Demonstrated productivity through first-author and collaborative publications in immunology

Job description:
To investigate the role of cell death sensing in regulating immune responses, with a particular focus on the contraction phase of T cell responses. This position seeks to elucidate how innate immune sensors detect dying T cells, and how this process influences the resolution of inflammation and the formation of memory T cells. The work involves integration of mouse models, flow cytometry-based immune profiling, and molecular dissection of cell death and efferocytosis pathways, aiming to uncover immune-regulatory mechanisms with relevance to infection, vaccination, and chronic inflammation.

Responsibilities:
* Design and conduct in vivo experiments using murine models to study immune regulation during T cell contraction and resolution of inflammation
* Perform high-dimensional flow cytometry for immune phenotyping and apoptosis/efferocytosis analysis
* Use molecular and cellular tools (e.g., gene knockdown, qPCR, antigen presentation assays) to dissect pathways of cell death sensing
* Conduct transcriptomic and pathway analyses (e.g., RNA-seq) to uncover regulatory networks
* Generate figures and contribute to manuscript writing and data presentations for publication and conferences
* Assist in maintaining and optimizing core immunological assays and cytometry platforms
* Present findings at lab meetings and scientific conferences; contribute to collaborative research discussions
* Prepare figures, methods, and manuscripts for publications
* Mentor junior trainees and contribute to the lab's knowledge-sharing and collaborative environment

Pay Range: $62,232 - $75,564 annually, follows NIH stipend level for experience; depending on education/qualifications/experience

Please visit the Benefits for Postdoctoral Candidates website for more information regarding benefit eligibility.

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training
• Medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and life insurance
• Employee wellbeing program
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will have the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

This position will remain open until filled.

To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647.

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