Scientist II, Bioconjugation Chemist

Who We Are

BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health.

Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities.

Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options.

• Engage actively in project team discussions across the organization, providing subject matter expertise to support the progression of research projects and the development of new methodologies.
• Work synergistically with multidisciplinary teams, including bioconjugation specialists, chemists, and biologists, to drive project success and foster a collaborative research environment.
• Design and synthesize bioconjugates such as antibody-oligo conjugates (AOCs), peptide conjugates, and other complex biomolecules.
• Develop and optimize conjugation methodologies and purification processes.
• Characterize bioconjugates using various analytical techniques, including HPLC, LC-MS, SDS-PAGE, and spectroscopy.
• Collaborate with cross-functional teams, including Biology, Pharmacology, and Process Development, to support preclinical and clinical programs.
• Maintain accurate and detailed laboratory records and documentation.
• Present research findings to internal teams and at scientific meetings.
• Stay up-to-date with the latest advancements in bioconjugation chemistry and related fields.

• Ph.D. in Chemistry, Biochemistry, or a related field with a focus on bioconjugation techniques and organic synthesis.
• Minimum of 3-5 years of postdoctoral experience or industry experience in bioconjugation chemistry.
• Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.
• Proven track record in designing and synthesizing bioconjugates, including AOCs and peptide conjugates.
• Strong knowledge of analytical techniques for characterizing bioconjugates.
• Excellent problem-solving skills and the ability to work independently and collaboratively.
• Strong written and verbal communication skills.

• Opportunity to work on cutting-edge biopharmaceuticals that make a meaningful impact on patients' lives.
• Collaborative and innovative work environment.
• Comprehensive benefits package, including health insurance, 401(k) matching, and professional development opportunities.
• Located in the beautiful San Francisco Bay Area with access to a vibrant scientific community.

• Demonstrated ability to work independently as well as part of a collaborative team environment, with a proactive approach to problem-solving and advancing research programs.
• Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.
• Commitment to maintaining up-to-date knowledge of advancements in oligonucleotide chemistry and related fields, with a willingness to engage in ongoing professional development.
• Expertise in solid-phase oligonucleotide synthesis and purification, with a strong track record of successful project outcomes.
• Excellent written and verbal communication skills, with the ability to effectively present data and findings to both technical and non-technical audiences.

• This is an onsite daily role in San Rafael, CA.
• This role will have a daily presence in our Research labs executing experiments.
• This position represents an exciting opportunity to contribute to BioMarin's mission of developing innovative therapies for patients with serious and life-threatening conditions. We look forward to welcoming a passionate and skilled oligonucleotide chemist to our team.

From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.

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Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.

Equal Opportunity Employer/Veterans/Disabled

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

• Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.