Client-Based Researcher

The Client-Based Researcher I position will work with the faculty leader, Dr. Josh Lang, in the fields of Human Molecular Biology and Cellular Immunology at the UW Carbone Cancer Center (UWCCC), as a member of the Circulating Biomarker Core (CBC). The focus of the CBC is to provide sample processing and analysis services to members of the UWCCC as well as the wider non-UW research community in-line with the development and clinical translation of biomarkers from the circulation that can predict or detect therapeutic resistance in patients with solid tumor diseases. Circulating biomarkers are evaluated on clinical specimens, primarily patient blood draws, through a series of sample processing steps, including ficoll density centrifugation, magnetic depletion of normal blood cells using standard MACS columns, magnetic enrichment and protein staining or nucleic acid (DNA/mRNA) extraction of metastatic tumor cells using either a customized pipetting robot or a handheld microfluidic device. Analytical systems include fluorescence microscopy image acquisition, raw image conversion into quantitative data using both automated image processing algorithms and manual review of identified objects.

Characterization of mRNA is achieved with reverse-transcription quantitative PCR (RT-qPCR). With the ultimate goal of implementing these circulating biomarker diagnostics into clinical practice, the CBC is also actively developing the controls and analytical validation datasets required for regulatory approval.

Our team of highly cooperative researchers coordinate the receipt, processing and analysis of 10-20 patient samples each week, testing a number of different protein and nucleic acid biomarkers, for numerous different projects involving basic research and clinical trials.

• 20% Assists with the development of research methodologies and procedures according to client-based objectives and specifications
• 20% Identifies concerns and recommends solutions to leadership
• 30% Collects and analyzes basic research data, conducts experiments and interviews, and documents results according to established policies and procedures
• 5% Prepares reports and materials and disseminates information to appropriate entities
• 10% Reviews and edits research protocols under general supervision
• 15% Trains individuals and groups on equipment operations, research protocols, and techniques within a specialized laboratory or research area

Diversity is a source of strength, creativity, and innovation for UW-Madison. We value the contributions of each person and respect the profound ways their identity, culture, background, experience, status, abilities, and opinion enrich the university community. We commit ourselves to the pursuit of excellence in teaching, research, outreach, and diversity as inextricably linked goals.

The University of Wisconsin-Madison fulfills its public mission by creating a welcoming and inclusive community for people from every background - people who as students, faculty, and staff serve Wisconsin and the world.

For more information on diversity and inclusion on campus, please visit: Diversity and Inclusion

Preferred
Bachelor's Degree
Preferably in Molecular Biology, Biochemistry, or other closely related biological science

Preferred:
- Previous experience in molecular biology methods, next generation sequencing, and immunology.
- Experience with microfluidic technologies and fluorescence microscopy, as well as a circulating
tumor cell research background.
- Previous experience in flow cytometry.

Full Time: 100%

It is anticipated this position requires work be performed in-person, onsite, at a designated campus work location.

Ongoing/Renewable

Minimum $44,000 ANNUAL (12 months)
Depending on Qualifications
The starting salary for the position is $44,000 but is negotiable based on experience and qualifications.

University sponsorship is not available for this position, including transfers of sponsorship and TN visas. The selected applicant will be responsible for ensuring their continuous eligibility to work in the United States (i.e. a citizen or national of the United States, a lawful permanent resident, a foreign national authorized to work in the United States without the need of an employer sponsorship) on or before the effective date of appointment. This position is an ongoing position that will require continuous work eligibility. If you are selected for this position you must provide proof of work authorization and eligibility to work.

To apply for this position, please click on the "Apply Now" button. You will be asked to upload a resume and cover letter as a part of the application process. Please ensure that the resume and cover letter address how you meet the minimum/preferred qualifications for the position. You may also be asked to provide three professional/supervisor references during the recruitment process. References will not be contacted prior to notifying you.

Devonne Tucker
dtucker@wisc.edu
608-263-9404
Relay Access (WTRS): 7-1-1. See RELAY_SERVICE for further information.

Client-Based Researcher I(RE001)

A53-MEDICAL SCHOOL/CARBONE CANC CTR/CANC CTR

Academic Staff-Renewable

314071-AS