Bacterial Core Lead Scientist

Eagle Health is seeking a Bacterial Core Lead Scientist to join our team in Fort Detrick, MD.

The employee shall serve as Lead Scientist and will conduct basic and applied research on specified bacterial threats, in support of the BD and infectious disease program. The Lead Scientist shall work in BSL-3 laboratories and thus must hold and maintain BPRP status, IAW the provisions in this contract and applicable regulations.

• Employee shall use computer to analyze data and prepare graphs, do statistics, write lab notes and reports.
• Employee shall complete 4 quarterly reports and 1 annual progress reports for DTRA per investigator
• Employee shall present 2 research findings/presentations at lab meetings and approximately 23 lab meetings per year, and if required, attend approximately 2 scientific meetings or symposia (CONUS or OCONUS).
• Employee shall attend 12 division meetings per year and give 1 presentation per investigator
• Employee shall prepare one 1st author manuscript for publication per year
• Employeeshall prepare approximately 2 supporting author scientific papers for publication.
• Employee in charge of maintenance of ~6 microscope systems in laboratories.
• Employee is responsible for ordering microscopy systems and parts.
• Employee shall prepare BSL-2 and BSL-3 labs for Safety, Bio-surety and CDC inspections four times a year.
• Employee shall plan and perform in vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria. We currently utilize 30-strain diversity sets of Bacillus anthracis (anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), Burkholderia mallei (glanders), and Burkholderia pseudomallei (meliodosis), testing over 72 compounds per year against all 30 strains, in vitro.
• Plan and participate in mouse, rat, and rabbit studies, which include preparation of antibiotics for administration, administering drugs and vaccines, orally and by intraperitoneal, intramuscular, subcutaneous, and intravenous administration. In addition, collect animal body fluids and remove tissues with all small-animal studies executed. Upon execution of experiment all employees will perform animal health exams to ensure study remains in compliance with IACUC approved protocols.
• Employee shall participate in weekly lab meetings and assist in development and design with current and future in vitro and in vivo work. May be requested to present posters at 1 scientific conferences which may require work to be performed outside normal business hours.
• Employee shall plan and participate in small-animal BSL-2 pharmacokinetics and toxicology studies; to include preparation of antibiotics for administration; administering drugs and vaccines, followed by blood and tissue collection of pharmacokinetic and pharmacodynamics relationships and efficacy of optimized leads.
• Employee shall support the in vivo pharmacology research program and contribute to the multidisciplinary research team to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads.
• Employee shall assist in approximately 4 animal protocols working with bacterial pathogens.
• Employee shall participate in testing and purifying B. anthracis components for efficacy studies.
• Employee shall write, plan and execute 1 animal protocol.
• Employee shall perform approximately 24 ELISAs per year.
• Employee shall process approximately 150 flow cytometry samples per year
• Employee will test for endotoxin and perform endotoxin remediation when necessary approximately 50 times per year.
• Employee shall purify approximately 16 bacterial products from culture supernatants per year.
• Employee shall conduct Equipment Inventory Management twice a year in BSL-2 and BSL-3
• Employee shall perform monthly Laboratory Management to include safety functions and chemical inventory.
• Provide 1 Scientific Support monthly report to TPOC by the last working day of the month. Report will include materials and methods, data and data analysis and should be updated monthly.
• Employee will maintain a GLP training folder and be compliant with all GLP regulations when applicable.
• CS-PRP enrollment is required and will be held and maintained IAW the provisions in this contract and all applicable regulations.
• BPRP enrollment is required and will be held and maintained IAW the provisions in this contract and all applicable regulations.